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Crown ethers attenuate aggregation of Amyloid beta of Alzheimer’s disease

The stagnant state of drug development for Alzheimer’s disease demands new approaches for seeking promising candidates. In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) peptide by crown ethers could inhibit its aggregation. To specifically target Aβs, a conjugate of Pi...

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Détails bibliographiques
Publié dans:Chem Commun (Camb)
Auteurs principaux: Tian, Yanli, Zhang, Xueli, Li, Yuyan, Shoup, Timothy M., Teng, Xin, Elmaleh, David R., Moore, Anna, Ran, Chongzhao
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617529/
https://ncbi.nlm.nih.gov/pubmed/25372154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc06029f
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