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Bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer’s disease

In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathy (CAAs). We also demonstrated that this imaging probe could inhibit...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Zhang, Xueli, Tian, Yanli, Yuan, Peng, Li, Yuyan, Yaseen, Mohammad A., Grutzendler, Jaime, Moore, Anna, Ran, Chongzhao
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617557/
https://ncbi.nlm.nih.gov/pubmed/25134928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc03731f
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