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Crown ethers attenuate aggregation of Amyloid beta of Alzheimer’s disease

The stagnant state of drug development for Alzheimer’s disease demands new approaches for seeking promising candidates. In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) peptide by crown ethers could inhibit its aggregation. To specifically target Aβs, a conjugate of Pi...

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Bibliographic Details
Published in:Chem Commun (Camb)
Main Authors: Tian, Yanli, Zhang, Xueli, Li, Yuyan, Shoup, Timothy M., Teng, Xin, Elmaleh, David R., Moore, Anna, Ran, Chongzhao
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617529/
https://ncbi.nlm.nih.gov/pubmed/25372154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc06029f
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