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Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions

Protein-protein interactions are among today’s most exciting and promising targets for therapeutic intervention. To date, identifying small-molecules that selectively disrupt these interactions has proven particularly challenging for virtual screening tools, since these have typically been optimized...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Bazzoli, Andrea, Kelow, Simon P., Karanicolas, John
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617380/
https://ncbi.nlm.nih.gov/pubmed/26484863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140359
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