Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia

Inherited anemias with ineffective erythropoiesis, such as β-thalassemia, manifest inappropriately low hepcidin production and consequent excessive absorption of dietary iron, leading to iron overload. Erythroferrone (ERFE) is an erythroid regulator of hepcidin synthesis and iron homeostasis. Erfe e...

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Publicat a:Blood
Autors principals: Kautz, Léon, Jung, Grace, Du, Xin, Gabayan, Victoria, Chapman, Justin, Nasoff, Marc, Nemeth, Elizabeta, Ganz, Tomas
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616236/
https://ncbi.nlm.nih.gov/pubmed/26276665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-658419
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