Murine erythroid 5-aminolevulinate synthase: Adenosyl-binding site Lys221 modulates substrate binding and catalysis

5-Aminolevulinate synthase (ALAS) catalyzes the initial step of mammalian heme biosynthesis, the condensation between glycine and succinyl-CoA to produce CoA, CO(2), and 5-aminolevulinate. The crystal structure of Rhodobacter capsulatus ALAS indicates that the adenosyl moiety of succinyl-CoA is posi...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Stojanovski, Bosko M., Ferreira, Gloria C.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
Subjects:
Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615937/
https://ncbi.nlm.nih.gov/pubmed/26605136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.09.009
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