Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs

Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism, both for research and therapeutic purposes. The shRNA precursor is processed by the RNase III-like enzyme Dicer into biologically active small interfering RNA (siRNA). This effector mole...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:RNA Biol
Hauptverfasser: Liu, Ying Poi, Karg, Margarete, Harwig, Alex, Herrera-Carrillo, Elena, Jongejan, Aldo, van Kampen, Antoine, Berkhout, Ben
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615756/
https://ncbi.nlm.nih.gov/pubmed/25826416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1017204
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