Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs

Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism, both for research and therapeutic purposes. The shRNA precursor is processed by the RNase III-like enzyme Dicer into biologically active small interfering RNA (siRNA). This effector mole...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Liu, Ying Poi, Karg, Margarete, Harwig, Alex, Herrera-Carrillo, Elena, Jongejan, Aldo, van Kampen, Antoine, Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615756/
https://ncbi.nlm.nih.gov/pubmed/25826416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1017204
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