Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs

Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism, both for research and therapeutic purposes. The shRNA precursor is processed by the RNase III-like enzyme Dicer into biologically active small interfering RNA (siRNA). This effector mole...

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Spremljeno u:
Bibliografski detalji
Izdano u:RNA Biol
Glavni autori: Liu, Ying Poi, Karg, Margarete, Harwig, Alex, Herrera-Carrillo, Elena, Jongejan, Aldo, van Kampen, Antoine, Berkhout, Ben
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615756/
https://ncbi.nlm.nih.gov/pubmed/25826416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1017204
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