Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension

OBJECTIVE: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular remodeling, resistance, and pressures. Reactive oxygen species (ROS) contribute to PH-associated vascular dysfunction. NADPH oxidases (Nox) and mitochondria are major sources of superoxide (O(2)(•−)) and hydrogen...

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Vydáno v:Free Radic Biol Med
Hlavní autoři: Adesina, Sherry E., Kang, Bum-Yong, Bijli, Kaiser M., Ma, Jing, Cheng, Juan, Murphy, Tamara, Hart, C. Michael, Sutliff, Roy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615392/
https://ncbi.nlm.nih.gov/pubmed/26073127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.05.042
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