Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension

Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance, pulmonary vascular remodeling, and increased pulmonary vascular pressures that often result in right ventricular dysfunction, leading to right heart failure. Evidence suggests that reactive oxygen species (ROS)...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Adesina, Sherry E., Wade, Brandy E., Bijli, Kaiser M., Kang, Bum-Yong, Williams, Clintoria R., Ma, Jing, Go, Young-Mi, Hart, C. Michael, Sutliff, Roy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451594/
https://ncbi.nlm.nih.gov/pubmed/28130258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00258.2016
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