Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells

Eitemau Tebyg

• mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation
  gan: Koo, Junghui, et al.
  Cyhoeddwyd: (2015)
• Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence
  gan: Kim, You-Mie, et al.
  Cyhoeddwyd: (2010)
• Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation
  gan: Koo, Junghui, et al.
  Cyhoeddwyd: (2015)
• Perifosine Inhibits mTOR Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy
  gan: Fu, Lei, et al.
  Cyhoeddwyd: (2009)
• FBXW7 Targets mTOR for Degradation and Genetically Cooperates with PTEN in Tumor Suppression
  gan: Mao, Jian-Hua, et al.
  Cyhoeddwyd: (2008)