Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells

Cancer cells feature increased de novo lipogenesis. Sterol regulatory element-binding protein 1 (SREBP1), when presented in its mature form (mSREBP1), enhances lipogenesis through increasing transcription of several of its target genes. Mammalian target of rapamycin (mTOR) complexes, mTORC1 and mTOR...

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Publicado en:Oncogene
Autores principales: Li, Shaohua, Oh, You-Take, Yue, Ping, Khuri, Fadlo R., Sun, Shi-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615269/
https://ncbi.nlm.nih.gov/pubmed/25893295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.123
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