Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements

PTCH1 gene codes for a 12-pass transmembrane receptor with a negative regulatory role in the Hedgehog-Gli signaling pathway. PTCH1 germline mutations cause Gorlin syndrome, a disorder characterized by developmental abnormalities and tumor susceptibility. The autosomal dominant inheritance, and the e...

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Publicado en:RNA Biol
Autores principales: Ozretić, Petar, Bisio, Alessandra, Musani, Vesna, Trnski, Diana, Sabol, Maja, Levanat, Sonja, Inga, Alberto
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615190/
https://ncbi.nlm.nih.gov/pubmed/25826662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1008929
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