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ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels
Despite extensive study, the mechanisms of cell fate choice upon p53 activation remain poorly understood. Using genome-wide shRNA screening, we recently identified the ATM kinase as synthetic lethal with Nutlin-3, an MDM2 inhibitor that leads to non-genotoxic p53 activation. Here, we demonstrate tha...
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| Publicado no: | Cell Cycle |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4614823/ https://ncbi.nlm.nih.gov/pubmed/25483068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.973330 |
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