Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4

Barrett's esophagus (BE) is defined as an incomplete intestinal metaplasia characterized generally by the presence of columnar and goblet cells in the formerly stratified squamous epithelium of the esophagus. BE is known as a precursor for esophageal adenocarcinoma. Currently, the cell of origi...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Vega, Maria E, Giroux, Véronique, Natsuizaka, Mitsuteru, Liu, Mingen, Klein-Szanto, Andres J, Stairs, Douglas B, Nakagawa, Hiroshi, Wang, Kenneth K, Wang, Timothy C, Lynch, John P, Rustgi, Anil K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614677/
https://ncbi.nlm.nih.gov/pubmed/25558829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.972875
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