PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2

Promyelocytic leukemia protein (PML) is emerging as an important tumor suppressor. Its expression is lost during the progression of several types of cancer, including lung cancer. The EGF receptor (EGFR), a membrane-bound receptor tyrosine kinase, transduces intracellular signals responsible for cel...

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Publicat a:Cell Cycle
Autors principals: Kuo, Hong-Yi, Huang, Yen-Sung, Tseng, Chin-Hsiu, Chen, Yi-Chen, Chang, Yu-Wei, Shih, Hsiu-Ming, Wu, Cheng-Wen
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614437/
https://ncbi.nlm.nih.gov/pubmed/25486572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.949212
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