Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice

De novo assembled alphoid(tetO)-type human artificial chromosomes (HACs) represent a novel promising generation of high capacity episomal vectors. Their function and persistence, and any adverse effects, in various cell types in live animals, have not, however, been explored. In this study we transf...

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Vydáno v:Cell Cycle
Hlavní autoři: Liskovykh, Mikhail, Ponomartsev, Sergey, Popova, Elena, Bader, Michael, Kouprina, Natalay, Larionov, Vladimir, Alenina, Natalia, Tomilin, Alexey
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614155/
https://ncbi.nlm.nih.gov/pubmed/25695642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1014151
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