Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice

De novo assembled alphoid(tetO)-type human artificial chromosomes (HACs) represent a novel promising generation of high capacity episomal vectors. Their function and persistence, and any adverse effects, in various cell types in live animals, have not, however, been explored. In this study we transf...

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Gepubliceerd in:Cell Cycle
Hoofdauteurs: Liskovykh, Mikhail, Ponomartsev, Sergey, Popova, Elena, Bader, Michael, Kouprina, Natalay, Larionov, Vladimir, Alenina, Natalia, Tomilin, Alexey
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614155/
https://ncbi.nlm.nih.gov/pubmed/25695642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1014151
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