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Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice

De novo assembled alphoid(tetO)-type human artificial chromosomes (HACs) represent a novel promising generation of high capacity episomal vectors. Their function and persistence, and any adverse effects, in various cell types in live animals, have not, however, been explored. In this study we transf...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Liskovykh, Mikhail, Ponomartsev, Sergey, Popova, Elena, Bader, Michael, Kouprina, Natalay, Larionov, Vladimir, Alenina, Natalia, Tomilin, Alexey
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614155/
https://ncbi.nlm.nih.gov/pubmed/25695642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1014151
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