AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol

Hypoxia-inducible factor 1 (HIF-1) transcriptionally promotes production of adenosine triphosphate (ATP) whereas AMPK senses and regulates cellular energy homeostasis. A histone deacetylase (HDAC) activity has been proven to be critical for HIF-1 activation but the underlying mechanism and its role...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Chen, Shuyang, Yin, Chengqian, Lao, Taotao, Liang, Dongming, He, Dan, Wang, Chenguang, Sang, Nianli
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614078/
https://ncbi.nlm.nih.gov/pubmed/26061431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1055426
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