The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis

Overexpression of cyclin D1 and its catalytic partner, CDK4, is frequently seen in human cancers. We constructed cyclin D1 and CDK4 protein interaction network in a human breast cancer cell line MCF7, and identified novel CDK4 protein partners. Among CDK4 interactors we observed several proteins fun...

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Publicado en:Cell Cycle
Autores principales: Jirawatnotai, Siwanon, Sharma, Samanta, Michowski, Wojciech, Suktitipat, Bhoom, Geng, Yan, Quackenbush, John, Elias, Joshua E, Gygi, Steven P, Wang, Yaoyu E, Sicinski, Piotr
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2014
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Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614005/
https://ncbi.nlm.nih.gov/pubmed/25486477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.946850
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