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Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation

BRCA2 plays an important role in the maintenance of genome stability by interacting with RAD51 recombinase through its C-terminal domain. This interaction is abrogated by cyclin A-CDK2-mediated phosphorylation of BRCA2 at serine 3291 (Ser3291). Recently, we showed that cyclin D1 facilitates RAD51 re...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Chalermrujinanant, Chonvara, Michowski, Wojciech, Sittithumcharee, Gunya, Esashi, Fumiko, Jirawatnotai, Siwanon
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538526/
https://ncbi.nlm.nih.gov/pubmed/26387543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.354
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