Elevated Glutathione Is Not Sufficient to Protect against Doxorubicin-Induced Nuclear Damage in Heart in Multidrug Resistance–Associated Protein 1 (Mrp1/Abcc1) Null Mice

Cardiotoxicity is a major dose-limiting adverse effect of doxorubicin (DOX), mediated in part by overproduction of reactive oxygen species and oxidative stress. Abcc1 (Mrp1) mediates the efflux of reduced and oxidized glutathione (GSH, GSSG) and is also a major transporter that effluxes the GSH conj...

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Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Deng, Jun, Coy, Donna, Zhang, Wei, Sunkara, Manjula, Morris, Andrew J., Wang, Chi, Chaiswing, Luksana, St. Clair, Daret, Vore, Mary, Jungsuwadee, Paiboon
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2015
Предметы:
Toxicology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613962/
https://ncbi.nlm.nih.gov/pubmed/26354996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225490
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