Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations

Telomerase reactivation and immortalization are critical for human carcinoma progression. However, little is known about the mechanisms controlling this crucial step, due in part to the paucity of experimentally tractable model systems that can examine human epithelial cell immortalization as it mig...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Garbe, James C, Vrba, Lukas, Sputova, Klara, Fuchs, Laura, Novak, Petr, Brothman, Arthur R, Jackson, Mark, Chin, Koei, LaBarge, Mark A, Watts, George, Futscher, Bernard W, Stampfer, Martha R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613853/
https://ncbi.nlm.nih.gov/pubmed/25485586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.954456
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