Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length

BACKGROUND: Shortening of telomeres, which are essential for maintenance of genomic integrity, is a mechanism commonly associated with the aging process. Here we ascertained whether changes in telomere lengths or telomerase activity correlated with age in normal human mammary epithelial cells (HMEC)...

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Hlavní autoři: Sputova, Klara, Garbe, James C, Pelissier, Fanny A, Chang, Eric, Stampfer, Martha R, LaBarge, Mark A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672013/
https://ncbi.nlm.nih.gov/pubmed/23718190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2041-9414-4-4
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