Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

Aberrant activation of SHH pathway is a major cause of medulloblastoma (MB), the most frequent brain malignancy of the childhood. A few Hedgehog inhibitors, all antagonizing the membrane transducer Smo, have been approved or are under clinical trials for the treatment of human MB. However, the effic...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Cycle
Main Authors: Di Magno, Laura, Manzi, Daniela, D’Amico, Davide, Coni, Sonia, Macone, Alberto, Infante, Paola, Di Marcotullio, Lucia, De Smaele, Enrico, Ferretti, Elisabetta, Screpanti, Isabella, Agostinelli, Enzo, Gulino, Alberto, Canettieri, Gianluca
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2014
Teme:
Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613849/
https://ncbi.nlm.nih.gov/pubmed/25485584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.952973
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