Antitumor Efficacy of Colon-Specific HPMA Copolymer/9-Aminocamptothecin Conjugates in Mice Bearing Human-Colon Carcinoma Xenografts

The antitumor activity of a colon-specific N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer – 9-aminocamptothecin (9-AC) conjugate (P-9-AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P-9-AC treatment of mice bearing orthotopic colon tumors, with a dose of 3 m...

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Publicado en:Macromol Biosci
Main Authors: Gao, Song-Qi, Sun, Yongen, Kopečková, Pavla, Peterson, C. Matthew, Kopeček, Jindřich
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613765/
https://ncbi.nlm.nih.gov/pubmed/19685500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mabi.200900147
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