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Biological Activity of Anti-CD20 Multivalent HPMA Copolymer-Fab’ Conjugates
High-molecular-weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab’ fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates with varying valency (amount of Fab’ per macromolecule) targeted to the B-cell antigen CD20. Th...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299848/ https://ncbi.nlm.nih.gov/pubmed/22288884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm201656k |
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