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Biological Activity of Anti-CD20 Multivalent HPMA Copolymer-Fab’ Conjugates

High-molecular-weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab’ fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates with varying valency (amount of Fab’ per macromolecule) targeted to the B-cell antigen CD20. Th...

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Autors principals: Johnson, Russell N., Kopečková, Pavla, Kopeček, Jindřich
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299848/
https://ncbi.nlm.nih.gov/pubmed/22288884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm201656k
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