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Anti-CD20 multivalent HPMA copolymer-Fab′ conjugates for the direct induction of apoptosis

A hybrid biomimetic system comprising high-molecular-weight, linear copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) grafted with multiple Fab′ fragments of anti-CD20 monoclonal antibody (mAb) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization followed by...

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書誌詳細
主要な著者: Chu, Te-Wei, Yang, Jiyuan, Kopeček, Jindřich
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572842/
https://ncbi.nlm.nih.gov/pubmed/22795544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.06.024
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