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Anti-CD20 multivalent HPMA copolymer-Fab′ conjugates for the direct induction of apoptosis
A hybrid biomimetic system comprising high-molecular-weight, linear copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) grafted with multiple Fab′ fragments of anti-CD20 monoclonal antibody (mAb) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization followed by...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3572842/ https://ncbi.nlm.nih.gov/pubmed/22795544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.06.024 |
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