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BIODISTRIBUTION AND PHARMACOKINETICS OF COLON-SPECIFIC HPMA COPOLYMER – 9-AMINOCAMPTOTHECIN CONJUGATE IN MICE
A water soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate was designed for oral colon-specific drug delivery for the treatment of colon cancer. Comparative studies between the polymer conjugate and free drug have been performed to assess their biodistr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1839958/ https://ncbi.nlm.nih.gov/pubmed/17150276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2006.10.024 |
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