BIODISTRIBUTION AND PHARMACOKINETICS OF COLON-SPECIFIC HPMA COPOLYMER – 9-AMINOCAMPTOTHECIN CONJUGATE IN MICE

A water soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer - 9-aminocamptothecin (9-AC) conjugate was designed for oral colon-specific drug delivery for the treatment of colon cancer. Comparative studies between the polymer conjugate and free drug have been performed to assess their biodistr...

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Bibliographic Details
Main Authors: Gao, Song-Qi, Lu, Zheng-Rong, Kopečková, Pavla, Kopeček, Jindřich
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839958/
https://ncbi.nlm.nih.gov/pubmed/17150276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2006.10.024
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