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Proteasome inhibitors suppress the protein expression of mutant p53
Tumor suppressor p53 is one of the most frequently mutated genes in cancer, with almost 50% of all types of cancer expressing a mutant form of p53. p53 transactivates the expression of its primary negative regulator, HDM2. HDM2 is a ubiquitin ligase, which initiates the proteasomal degradation of p5...
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| 發表在: | Cell Cycle |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613555/ https://ncbi.nlm.nih.gov/pubmed/25485499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.950132 |
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