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Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors

The oncogenic transcription factor FOXM1 is one of the key regulators of tumorigenesis. We found that FOXM1 upregulates its own transcription and its protein stability depends on its interaction with the chaperone nucleophosmin. We also determined that FOXM1 is negatively regulated by the tumor supp...

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Detalhes bibliográficos
Autor principal: Gartel, Andrei L.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095980/
https://ncbi.nlm.nih.gov/pubmed/25093142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/596528
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