The mucolipidosis IV Ca(2+) channel TRPML1 (MCOLN1) is regulated by the TOR kinase

Autophagy is a complex pathway regulated by numerous signalling events that recycles macromolecules and may be perturbed in lysosomal storage disorders (LSDs). During autophagy, aberrant regulation of the lysosomal Ca(2+) efflux channel TRPML1 [transient receptor potential mucolipin 1 (MCOLN1)], als...

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Publicat a:Biochem J
Autors principals: Onyenwoke, Rob U., Sexton, Jonathan Z., Yan, Feng, Díaz, María Cristina Huertas, Forsberg, Lawrence J., Major, Michael B., Brenman, Jay E.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613499/
https://ncbi.nlm.nih.gov/pubmed/26195823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150219
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