Neuropathology of the Mcoln1(−/−) Knockout Mouse Model of Mucolipidosis Type IV

The recently developed Mcoln1(−/−) knockout mouse provides a novel model for analyzing mucolipin 1 (TRP-ML1) function and mucolipidosis type IV (MLIV) disease. Here we characterize the neuropathology of the Mcoln1(−/−) mouse at the end stage. Evidence of ganglioside accumulation, including increases...

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Detalhes bibliográficos
Publicado no:J Neuropathol Exp Neurol
Main Authors: Micsenyi, Matthew C., Dobrenis, Kostantin, Stephney, Gloria, Pickel, James, Vanier, Marie T., Slaugenhaupt, Susan A., Walkley, Steven U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232971/
https://ncbi.nlm.nih.gov/pubmed/19151629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181942cf0
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