RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells

Though RecQL4 was shown to be essential for the initiation of DNA replication in mammalian cells, its role in initiation is poorly understood. Here, we show that RecQL4 is required for the origin binding of Mcm10 and Ctf4, and their physical interactions and association with replication origins are...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Im, Jun-Sub, Park, Soon-Young, Cho, Won-Ho, Bae, Sung-Ho, Hurwitz, Jerard, Lee, Joon-Kyu
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612657/
https://ncbi.nlm.nih.gov/pubmed/25602958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1007001
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