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Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

[Image: see text] Lysine 2,3-aminomutase (LAM) is a radical S-adenosyl-L-methionine (SAM) enzyme and, like other members of this superfamily, LAM utilizes radical-generating machinery comprising SAM anchored to the unique Fe of a [4Fe-4S] cluster via a classical five-membered N,O chelate ring. Catal...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Horitani, Masaki, Byer, Amanda S., Shisler, Krista A., Chandra, Tilak, Broderick, Joan B., Hoffman, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612528/
https://ncbi.nlm.nih.gov/pubmed/25923449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00498
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