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CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance
Autoimmunity results from a breakdown in central or peripheral tolerance. To establish central tolerance, developing T cells must enter the thymic medulla, where they scan antigen-presenting cells (APCs) displaying a diverse array of autoantigens. If a thymocyte is activated by a self-antigen, the c...
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| Pubblicato in: | J Exp Med |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612092/ https://ncbi.nlm.nih.gov/pubmed/26417005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150178 |
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