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CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction
Following positive selection, thymocytes migrate into the medulla where they encounter diverse self-antigens that induce central tolerance. Thymocytes expressing T cell receptors (TCRs) with high affinity for self-antigens displayed by medullary antigen presenting cells (APCs) undergo either negativ...
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| Pubblicato in: | PLoS One |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6053179/ https://ncbi.nlm.nih.gov/pubmed/30024927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200765 |
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