Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis

Bone surfaces attract hematopoietic and nonhematopoietic cells, such as osteoclasts (OCs) and osteoblasts (OBs), and are targeted by bone metastatic cancers. However, the mechanisms guiding cells toward bone surfaces are essentially unknown. Here, we show that the Gαi protein–coupled receptor (GPCR)...

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Publicado en:J Exp Med
Main Authors: Nevius, Erin, Pinho, Flavia, Dhodapkar, Meera, Jin, Huiyan, Nadrah, Kristina, Horowitz, Mark C., Kikuta, Junichi, Ishii, Masaru, Pereira, João P.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612084/
https://ncbi.nlm.nih.gov/pubmed/26438360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150088
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