Low load for disruptive mutations in autism genes and their biased transmission

We previously computed that genes with de novo (DN) likely gene-disruptive (LGD) mutations in children with autism spectrum disorders (ASD) have high vulnerability: disruptive mutations in many of these genes, the vulnerable autism genes, will have a high likelihood of resulting in ASD. Because indi...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Iossifov, Ivan, Levy, Dan, Allen, Jeremy, Ye, Kenny, Ronemus, Michael, Lee, Yoon-ha, Yamrom, Boris, Wigler, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611648/
https://ncbi.nlm.nih.gov/pubmed/26401017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516376112
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