Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer()()

STAT3 activation is associated with poor prognosis in human colorectal cancer (CRC). Our previous data demonstrated that regorafenib (Stivarga) is a pharmacological agonist of SH2 domain-containing phosphatase 1 (SHP-1) that enhances SHP-1 activity and induces apoptosis by targeting STAT3 signals in...

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Veröffentlicht in:Neoplasia
Hauptverfasser: Fan, Li-Ching, Teng, Hao-Wei, Shiau, Chung-Wai, Tai, Wei-Tien, Hung, Man-Hsin, Yang, Shung-Haur, Jiang, Jeng-Kai, Chen, Kuen-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611073/
https://ncbi.nlm.nih.gov/pubmed/26476076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.08.007
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