The C-terminus of Apc does not influence intestinal adenoma development or progression

Adenomatous polyposis coli (APC) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C-terminal domains that interact with the cytoskeleton. The importance of Wnt dysregulation for colore...

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Опубликовано в: :J Pathol
Главные авторы: Lewis, Annabelle, Davis, Hayley, Deheragoda, Maesha, Pollard, Patrick, Nye, Emma, Jeffery, Rosemary, Segditsas, Stefania, East, Philip, Poulsom, Richard, Stamp, Gordon, Wright, Nicholas, Tomlinson, Ian
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610063/
https://ncbi.nlm.nih.gov/pubmed/22009253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.2972
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