Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

In order to identify new genes with differential expression in early intestinal tumours, we performed mRNA (messenger ribonucleic acid) expression profiling of 16 human and 63 mouse adenomas. All individuals had germline APC mutations to ensure that tumorigenesis was driven by ‘second hits’ at APC....

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Auteurs principaux: Segditsas, Stefania, Sieber, Oliver, Deheragoda, Maesha, East, Phil, Rowan, Andrew, Jeffery, Rosemary, Nye, Emma, Clark, Susan, Spencer-Dene, Bradley, Stamp, Gordon, Poulsom, Richard, Suraweera, Nirosha, Silver, Andrew, Ilyas, Mohammad, Tomlinson, Ian
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2008
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638572/
https://ncbi.nlm.nih.gov/pubmed/18782851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn286
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