Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease

Stroke and vascular dementia are leading causes of morbidity and mortality. Neuroprotective therapies have been proposed but none have proven clinically tolerated and effective. While overstimulation of N-methyl-d-aspartate-type glutamate receptors (NMDARs) is thought to contribute to cerebrovascula...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Takahashi, Hiroto, Xia, Peng, Cui, Jiankun, Talantova, Maria, Bodhinathan, Karthik, Li, Wenjun, Holland, Emily A., Tong, Gary, Piña-Crespo, Juan, Zhang, Dongxian, Nakanishi, Nobuki, Larrick, James W., McKercher, Scott R., Nakamura, Tomohiro, Wang, Yuqiang, Lipton, Stuart A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609936/
https://ncbi.nlm.nih.gov/pubmed/26477507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14781
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