Pioglitazone Attenuates Acute Cocaine Toxicity in Rat Isolated Heart: Potential Protection by Metabolic Modulation

BACKGROUND: The authors test whether cocaine depresses mitochondrial acylcarnitine exchange and if a drug that enhances glucose metabolism could protect against cocaine-induced cardiac dysfunction. METHODS: Oxygen consumption with and without cocaine was compared in rat cardiac mitochondria using ei...

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Publicado en:Anesthesiology
Autores principales: Weinberg, Guy L., Ripper, Richard, Bern, Sarah, Lin, Bocheng, Edelman, Lucas, DiGregorio, Guido, Piano, Mariann, Feinstein, Douglas L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609210/
https://ncbi.nlm.nih.gov/pubmed/21487283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318218a7f6
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