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pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit
Disposal of damaged mitochondria is tightly controlled by auto-inhibition mechanisms that keep the ubiquitin ligase Parkin in check. Several new structural studies provide insight into how PINK1-dependent phosphorylation of ubiquitin and Parkin may progressively relieve Parkin auto-inhibition.
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| Publié dans: | EMBO J |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley & Sons, Ltd
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609180/ https://ncbi.nlm.nih.gov/pubmed/26346274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592857 |
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