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How DNA vicinity controls SUMO E3 ligase activity

Little is known about the regulation of SUMO E3 ligases and how they are activated upon stress. New findings from the Reverter and Torres‐Rosell laboratories in The EMBO Journal demonstrate that vicinity of preferentially ssDNA activates the SUMO E3 ligase Nse2 when in complex with SMC5‐6.

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Bibliographic Details
Published in:EMBO J
Main Author: Pichler, Andrea
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003651/
https://ncbi.nlm.nih.gov/pubmed/29794112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899705
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