pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit

Disposal of damaged mitochondria is tightly controlled by auto-inhibition mechanisms that keep the ubiquitin ligase Parkin in check. Several new structural studies provide insight into how PINK1-dependent phosphorylation of ubiquitin and Parkin may progressively relieve Parkin auto-inhibition.

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Bibliographic Details
Published in:EMBO J
Main Authors: Dove, Katja K, Klevit, Rachel E, Rittinger, Katrin
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
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News & Views
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609180/
https://ncbi.nlm.nih.gov/pubmed/26346274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592857
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