Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells

BACKGROUND: Amidation of the carboxyl terminal of many peptides is essential for full biological potency, often increasing receptor binding and stability. The single enzyme responsible for this reaction is peptidylglycine α-amidating monooxygenase (PAM: EC 1.14.17.3), a copper- and ascorbate-depende...

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Pubblicato in:BMC Biotechnol
Autori principali: Carlson, Kristina, Pomerantz, Steven C., Vafa, Omid, Naso, Michael, Strohl, William, Mains, Richard E., Eipper, Betty A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609047/
https://ncbi.nlm.nih.gov/pubmed/26475607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0210-4
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