Hydroxybenzaldoximes are d-GAP-competitive inhibitors of E. coli 1-deoxy-d-xylulose-5-phosphate synthase

1-Deoxy-d-xylulose 5-phosphate (DXP) synthase is the first enzyme in the methylerythritol phosphate pathway to essential isoprenoids in pathogenic bacteria and apicomplexan parasites. In bacterial pathogens, DXP lies at a metabolic branchpoint, serving also as a precursor in the biosynthesis of vita...

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Vydáno v:Chembiochem
Hlavní autoři: Bartee, David, Morris, Francine, Al-khouja, Amer, Freel Meyers, Caren L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609000/
https://ncbi.nlm.nih.gov/pubmed/26174207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500119
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