Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen

Vinculin is filamentous (F)-actin-binding protein enriched in integrin-based adhesions to the extracellular matrix (ECM). Whereas studies in 2-dimensional (2D) tissue culture models have suggested that vinculin negatively regulates cell migration by promoting cytoskeleton–ECM coupling to strengthen...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Thievessen, Ingo, Fakhri, Nikta, Steinwachs, Julian, Kraus, Viola, McIsaac, R. Scott, Gao, Liang, Chen, Bi-Chang, Baird, Michelle A., Davidson, Michael W., Betzig, Eric, Oldenbourg, Rudolf, Waterman, Clare M., Fabry, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608908/
https://ncbi.nlm.nih.gov/pubmed/26195589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-268235
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